Hexokinase Activity in Brain

Studies on hexokinase. 1. The hexokinase activity of rat-brain extracts.

Effect of different thyroid states on mitochondrial porin synthesis and hexokinase activity in developing rabbit brain.

Voltage-dependent anion-selective channel proteins (VDACs) are pore-forming proteins found in the outer mitochondrial membrane of all eukaryotes and in brain postsynaptic membranes. VDACs regulate anion fluxes of a series of metabolites including ATP, thus regulating mitochondrial metabolic functions. Hexokinase binds to porin. The mitochondrially bound hexokinase can greatly increase the rate ...

Kinetic studies of the brain hexokinase reaction.

The mechanism of the hexokinase reaction has been the subject of numerous investigations in recent years (l-5). ijgren and Engstrijm reported the incorporation of Pa from labeled adenosine triphosphate (ATP) into the phosphoserine moiety of hexokinase in the absence of substrate glucose and concluded that an enzyme-phosphate intermediate participated in the reaction (2). Gamble and Najjar, howe...

Inhibitors and activators of brain hexokinase.

Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain

In hyperglycemia, glucagon-like peptide-1 (GLP-1) lowers brain glucose concentration together with increased net blood-brain clearance and brain metabolism, but it is not known whether this effect depends on the prevailing plasma glucose (PG) concentration. In hypoglycemia, glucose depletion potentially impairs brain function. Here, we test the hypothesis that GLP-1 exacerbates the effect of hy...